Using a modified Fibonacci method, we performed a phase I and pharmacokinetic study of aplidine administered as a 24hour intravenous infusion every 2 weeks. Results Sixtyseven patients received aplidine at a dose ranging from 0. 2 to 8 mgm 2.Plitidepsin (also known as dehydrodidemnin B, marketed by PharmaMar, S. A. under the trade name Aplidin) is a chemical compound extracted from the ascidian Aplidium albicans. It is currently undergoing clinical trial testing. aplidine pdf
Aplidine is a new marine anticancer depsipeptide isolated from the Mediterranean tunicate Aplidium albicans. We have evaluated its antiproliferative action against a variety of freshly explanted human tumour specimens. Concentration ranges of microM and microM were used in short and longterm exposure schedules respectively.
At the administered dose, aplidine quickly disappeared from plasma with a halflife of 9 min. and was detectable, but not quantifiable, in samples collected after 20 min. The excretion of aplidine was assayed by the quantification of unmodified aplidine in the urine samples. Aplidine is a new cyclic depsipeptide with anticancer activity in vitro and in vivo in different tumour types, but it has not been tested in pancreatic carcinoma. Nevertheless, this pathology has a poor prognosis because of difficult early diagnosis, aggressiveness and lack of effective systemic therapies. aplidine pdf PDF Aplidine is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans.
Aplidine synthesis essay. Ielts task 2 essay topics new description city essay clean your essay proposals examples by filipino authors. Essay about music in school jobs in nepali psychology in my life essay missionary a change of heart about animals persuasive essay an elephant essay book pdf. aplidine pdf Aplidine is supplied and stored as a sterile lyophilised product, consisting of aplidine and excipient in a formulation adequate for therapeutic use. [0056 Solubilised aplidine shows substantial degradation under heat and light stress testing conditions, and a lyophilised dosage form was developed, see WO incorporated herein by reference. Jun 08, 2004 Aplidine, dehydrodidemnin B, is a marinederived antitumour agent isolated from the Mediterranean tunicate Aplidium albicans (Sakai et al, 1996; da Rocha et al, 2001; Jimeno, 2002; Vera and Joullie, 2002). It is a cyclic depsipeptide, structurally related to other naturally occurring didemnins, such as didemnin B. Aplidine is a new marinederived anticancer chemical entity identified from the Mediterranean tunicate Aplidium albicans. Aplidine is a cyclic depsipeptide (Figure 1) structurally related to Rapid and Selective Apoptosis in Human Leukemic Cells Induced by Aplidine through a FasCD95 and Mechanism1 Consuelo Gajate, Feiyun An, 2 and Faustino Mollinedo3 Centro de Investigacion del Cancer, Instituto de Biologa Molecular yRating: 4.35 / Views: 455